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Dear Customers and Partners,

Please find the next edition of the Monthly Infectious Diseases Summary, our subjective look at the most important news of the month. Please let us know how you like it and if there is something interesting we missed, contact us at this email address. 

 

Shiga toxin-producing E. coli (STEC) O145 outbreak in the UK

Article
 

Ecoli-stockAn E. coli outbreak in the UK has triggered extensive recalls of pre-packaged sandwiches, wraps, and salads, with the number of confirmed cases reaching 275 as of June 25. The UK Health Security Agency (UKHSA) traced the contamination to a product distributed nationwide, affecting major supermarkets. From June 14, companies like Greencore Group, Samworth Brothers Manton Wood, and the vegan brand THIS! started recalling products from retailers including Sainsbury’s, Tesco, and WH Smith. Read more here. 

The outbreak involves Shiga toxin-producing E. coli (STEC), which poses significant health risks, especially to vulnerable groups. Health officials recommend thorough cooking, proper washing of produce, and frequent handwashing to prevent infection. People with symptoms should avoid handling food and contact with at-risk individuals until they fully recover. 

To address the situation, the Food Standards Agency (FSA) and Food Standards Scotland (FSS) have issued precautionary recalls and are collaborating with public health agencies to perform epidemiological and genomic analyses. These efforts aim to pinpoint the outbreak's source and establish preventive measures to protect public health. Read more here. 

The Native Antigen company offers E.coli O145 Antigen intended for use as a positive control in immunoassay development for E. coli detection and a Selection of other E. coli Antigens and Antibodies Tailored for ELISA testing. 

 

Tiger Mosquitoes Drive Surge in Dengue Fever Cases Across Europe

Article

 

An invasive mosquito species has established itself in 13 EU countries, including France, Spain, and Greece, and experts are linking its presence to an increase in dengue fever cases in Europe. The European Centre for Disease Prevention and Control (ECDC) attributes the spread of the tiger mosquito to favorable conditions created by climate change. 

Authorities in Paris, where the Olympic Games will take place at the end of July, have been monitoring and trapping the insect. The ECDC has warned that international travel could further elevate the risk of European outbreaks. They advise people to eliminate stagnant water from gardens and balconies, use mosquito repellent, and install screens on windows and doors. 

Over the past two decades, mosquitoes have become an increasing threat in Europe. The Asian tiger mosquito, Aedes albopictus, considered the most invasive mosquito species globally, is spreading across Europe from its initial southern European base. It is now established in Austria, Bulgaria, Croatia, France, Germany, Greece, Hungary, Italy, Malta, Portugal, Romania, Slovenia, and Spain. It has also been recorded in Belgium, Cyprus, Czechia, the Netherlands, and Slovakia. 

Tiger mosquitoes are known to spread diseases such as dengue fever, chikungunya, and Zika virus, which were previously confined to parts of Africa, Asia, and the Americas. Another mosquito, Aedes aegypti, which transmits yellow fever and other diseases, has established itself in Cyprus. Experts are concerned about its potential spread to other parts of Europe due to its preference for biting humans and its ability to transmit diseases. Read more here. 

See all our Flavivirus products here and do not hesitate to enquire about the pricing of our best-selling Dengue VLPs, perfect for the development of next-generation diagnostic assays! 

TEM Image of Dengue-2 VLPs

Figure 1. TEM Image of Dengue-2 Virus-like Particles

 

 

UK Raises Alarm After Detecting Potentially Lethal Meningococcal Disease 

Article
 

iStock-1359719366_MeningitisThe Foreign Office has issued an urgent health warning after three British travelers were diagnosed with meningococcal disease upon their return to the UK. The warning noted that 14 cases of the invasive infection have been reported among travelers to Saudi Arabia, including three cases in the UK, five in the US, four in France, and one each in Norway and the Netherlands. 

According to Travel Health Pro, a website supported by the Foreign Office, those diagnosed had recently returned from the Hajj pilgrimage to Saudi Arabia. The disease, caused by the bacterium Neisseria meningitidis, can lead to meningitis, which is the inflammation of the protective membranes covering the brain and spinal cord. 

Meningococcal disease progresses rapidly and can be fatal, with a mortality rate of up to 15 percent. It is most common in infants under one year old, teenagers, young adults aged 16 to 23, and individuals aged 65 and older. Read more here. 

 

ECDC Calls for Vigilance as STI Cases Increase

Article

 

Chlamydia__Bacteria_iStock_000074521335_Large-1-2On June 3rd, the European Centre for Disease Prevention and Control (ECDC) responded to a concerning rise in sexually transmitted infections (STIs) across Europe by urging the public to stay informed and practice safer sex during summer holidays, festivals, and travel. This warning coincides with the ECDC's 2024 data release, revealing troubling trends in infections like chlamydia, gonorrhea, and syphilis, all of which have shown an increase in reported cases. These infections, while treatable, can lead to serious health complications such as pelvic inflammatory disease, chronic pain, infertility from chlamydia and gonorrhea, and neurological and cardiovascular issues from syphilis. Untreated syphilis in pregnancy can also result in severe outcomes for children. Read more here. 

In addition to these concerns, there is a growing alarm over rising antimicrobial resistance (AMR) in Neisseria gonorrhoeae. The ECDC's report on June 10 emphasized the importance of continuous monitoring to guide effective treatment and prevention strategies, particularly as gonorrhea cases continue to rise across Europe. This underscores the critical need for judicious antimicrobial use to combat resistance and ensure effective treatment outcomes. Read more here. 

 

The Native Antigen Company is pleased to announce the launch of Recombinant Neisseria gonorrhea RmpM Antigen. This recombinant antigen, expressed in E.coli, is an ideal candidate for vaccine components and therapeutic targets. 

In our commitment to comprehensive STI studies, we have also developed a portfolio of HIV gp140 antigens enabling a new generation of diagnostic assays and structural studies, see the whole range here, and a wide range of Hepatitis B products and Herpes simplex raw materials ideal for your immunoassay. 

Read more about advantages of our novel HIV antigens portfolio in the blog: New Tools for HIV Diagnosis  and see our website for other existing antigens of STI pathogens.

 

WHO and Scientists Advocate Immediate Action on Highly Dangerous Mpox Strain 

Article

 

Mpox-StockThe World Health Organization (WHO) has highlighted the urgent need to address the mpox outbreak in Africa, particularly a dangerous strain in the Democratic Republic of Congo (DRC). As of June 26, 2024, South Africa reported 16 confirmed cases of mpox, including three deaths, marking the first fatalities from the disease in the country since August 2022. Previously, South Africa had only reported five cases and no deaths between June and August 2022. Read more here. 

In the DRC's South Kivu province, a mutated clade I strain of mpox has been identified, with fatality rates of approximately 5% in adults and 10% in children. This year, the DRC has recorded about 8,600 mpox cases and 410 deaths. 

Mpox is a viral infection transmitted through close contact, causing flu-like symptoms and pus-filled lesions. While most cases are mild, the virus can be fatal. A less severe clade IIb strain spread globally in 2022, primarily through sexual contact among men who have sex with men, prompting a WHO public health emergency declaration. Despite the end of the emergency, recent deaths in South Africa underscore the ongoing health threat. 

Challenges in combating the outbreak in the DRC include stigma, limited availability of vaccines and treatments, and the need for vaccine approval. Efforts are underway to address these challenges, including collaboration with vaccine manufacturers and urging expedited approval processes and data provision from countries. Read more here. 

Have a look at our full range of Mpox productshere and at the paperAPOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016. 

 

Meet Our Team

Hafsah Hussain, Junior Research Scientist

 

 

Hatsah Hussain       

I grew up in the town of High Wycombe in the UK and later moved to the picturesque city of Canterbury in Kent to pursue an undergraduate degree in Biomedical Science. During my final year, I worked on a research project that investigated the phosphorylation of amino acids in yeast cells. This hands-on laboratory experience ignited my passion for research. 

After graduating, I began my career in a COVID-19 lighthouse laboratory, where I processed COVID-19 sample swabs as part of the QPCR team. Seeking a change from high-throughput processing, I transitioned to a role as a Production Technician at The Native Antigen Company LGC in Kidlington. It was here that my interest in protein purification took root. Currently, I work as a Junior Research Scientist in the Downstream Processing Development team, where I test and develop techniques to purify a variety of antigens and antibodies for our customers. I find immense satisfaction in research, as it constantly challenges me and allows me to expand my skill set. 

In my free time, I enjoy long walks, studying for my diploma in Islamic education, volunteering at my local mosque, and partaking in extreme sports activities such as skydiving.

 
In case you missed it...
Resources
 

We keep our content up to date so that you can stay in touch with the news and resources that are the latest and greatest for everything "Antibodies and Antigens." Check out the latest below.

New products: Nipah and Hendra glycoproteins

Nipah virus is a prime example of the dangers posed by zoonotic diseases, which can cross from animals to humans, leading to serious infections.  

 

The Native Antigen Company is excited to share we have expanded our Paramyxoviridae antigen portfolio to include the Hendra virus glycoprotein G,Nipah virus glycoprotein G-Bangladesh, and Nipah virus glycoprotein G- Malaysia. These glycoproteins are presented tag-free, ensuring cross-reactivity with typical purification handles such as Fc-tags is avoided in your assay design. 

 

Follow us onLinkedIn to keep up to date with our newest product launches! 

Enhance your antigen assay development with one of our newest tool!

 Matched Pair Antibodies

Check out this Quick-reference Guide to Common Human Pathogenic Viruses on our website.

Click access now below to download the online version now or contact us to order your free copy at nac.contact@lgcgroup.com.

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